Neutrophil activation in ivermectin-treated onchocerciasis patients
نویسندگان
چکیده
منابع مشابه
Evaluation of Lymphatic Filariasis and Onchocerciasis in Three Senegalese Districts Treated for Onchocerciasis with Ivermectin
In Africa, onchocerciasis and lymphatic filariasis (LF) are co-endemic in many areas. Current efforts to eliminate both diseases are through ivermectin-based mass drug administration (MDA). Years of ivermectin distribution for onchocerciasis may have interrupted LF transmission in certain areas. The Kédougou region, Senegal, is co-endemic for LF and onchocerciasis. Though MDA for onchocerciasis...
متن کاملSustainable Control of Onchocerciasis: Ocular Pathology in Onchocerciasis Patients Treated Annually with Ivermectin for 23 Years: A Cohort Study
UNLABELLED The evolution and persistence of ocular pathology was assessed in a cohort of Onchocerca volvulus infected patients treated annually with ivermectin for 23 years. Patients were resident in rural Central and Kara Region of Togo and ocular examinations included testing of visual acuity, slit lamp examination of the anterior eye segment and the eye fundus by ophthalmoscopy. Before iverm...
متن کاملCan ivermectin mass treatments eliminate onchocerciasis in Africa?
OBJECTIVE To elucidate the conditions in which mass treatment with ivermectin reduces the transmission of Onchocerca volvulus sufficiently to eliminate infection from an African community. METHODS ONCHOSIM, a microsimulation model for onchocerciasis transmission, was used to explore the implications of different treatment intervals, coverage levels and precontrol endemicities for the likeliho...
متن کاملPossible pathogenic pathways in the adverse clinical events seen following ivermectin administration to onchocerciasis patients.
BACKGROUND: Reactions are commonly associated with the chemotherapy of onchocerciasis. However unmanageable reactions are uncommon when ivermectin (Mectizan(R)) is used for the treatment of this infection, and this drug has proved to be a great improvement over previously used agents. Serious adverse events (SAE) nevertheless have occurred, and there is considerable concern about the negative e...
متن کاملEntomological evaluation of ivermectin mass treatment against onchocerciasis.
To evaluate the impact of onchocerciasis control programmes on the annual transmission potential, it is customary to monitor the man-biting rate of vector Siniuliuin (Diptera: Simuliidae) and the number of Oizclzocerca (Nematoda: Onchocercidae) infective larvae found in them (Walsh et al., 1978). In addition to the transmission of Onchocerca volvulus (Leuckart) causing human onchocerciasis, Sim...
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ژورنال
عنوان ژورنال: Clinical & Experimental Immunology
سال: 2008
ISSN: 0009-9104
DOI: 10.1111/j.1365-2249.1993.tb03452.x